Topical steroids

Timeframes for using topical steroids can vary, depending on the age of the person using them, the severity of their eczema and the body site affected. Topical steroids are usually used for between 7 and 14 days, although sometimes a shorter timeframe (for example, 5-7 days) might be advised. After using a potent or very potent topical steroid for 7 days, you might be advised to step down to a lower potency steroid for a further 7 days. Some doctors recommend continuing to apply a topical steroid for 2 days after a flare has resolved, to prevent rebound flaring. Research shows that topical steroids only need to be applied once a day; using them twice a day does not provide any additional benefit.

After a short treatment burst of the kind described above, it’s important to have a steroid break. There is no agreed-upon length of time for this. Doctors generally recommend a steroid break of at least 2 weeks, but 4 weeks might be advised after using potent or very potent topical steroids.

People with more severe eczema who experience very frequent flares are sometimes advised to use topical steroids as ‘weekend therapy’ rather than for the kind of timeframe described above. Weekend therapy is when topical steroids are applied on 2 consecutive days a week to the areas where the eczema usually flares, for several months at a time. This can help prevent the almost continuous flare cycle, meaning that in the long-run, less topical steroid is needed to control the eczema than if each flare were treated as it occurred.

Using steroids more frequently or for longer periods of time than advised by your healthcare professional will not be of benefit in controlling your eczema and could be harmful to the skin on a long-term basis. Conversely, not using enough topical steroid or using very small amounts continuously often results in it not working so well and perhaps more being used in the long-term.

Topical steroids are effective treatments for eczema, but like many medicines, they can have side effects including thinning of the skin. When used for short treatment bursts as directed by a healthcare professional, and applied to areas of affected skin only, the risk of side effects is small. Experience of using topical steroids gained over many years shows the benefits of correct use vastly outweigh the risks.

The likelihood of side effects occurring is related to the potency of the preparation, where it is used, the condition of the skin on which it is used and the age of the person using it. All these factors will be taken into consideration when a prescription is given to treat eczema.

Some people with eczema are concerned about possible side effects when they stop using topical steroids. Topical steroid withdrawal (TSW) reactions are more likely to occur when stopping treatment after prolonged, continuous use of higher potency topical steroids, for usually more than a year. People undergoing TSW reactions experience symptoms worse than their original condition. Symptoms include red or darker burning skin (darker than a person’s usual skin colour, depending on skin tone) often in areas where they have never had eczema before. They can feel tired and weak and may even be bed-bound.

If used over long periods of time, topical steroids can thin the skin, making it appear transparent, fragile and susceptible to bruising. Blood vessels may become more prominent, and the skin can lose its elasticity, developing ‘stretch marks’. Other possible side effects include increased hair growth of very fine hair and perioral dermatitis (a spotty rash around the mouth). However, these effects usually only occur when potent or very potent steroids have been applied for a long period of time, either to the face or to covered parts of the body such as the flexures. Skin thinning can also occur when steroids have been applied under occlusion (for example, under bandages or gloves). For these reasons, topical occlusion should be limited to short periods of time under the supervision of a doctor or nurse.

There is also a small risk from topical steroids being absorbed into the blood through the skin. Again, the likelihood of this occurring is directly linked to the amount and potency of steroid used and the age of the person using it. The main problem relating to the absorption of steroids is suppression of the body’s own steroid production by the adrenal glands. This is called ‘hypoadrenalism’ and causes severe weakness and low blood pressure.

Adverse effects are less likely to occur if potent and very potent topical steroids are limited in use and are replaced by weaker steroids once they have brought a flare-up under control. Keeping up a daily routine of using emollients for moisturising and washing to repair the skin barrier and prevent dry skin has been shown to reduce the amount of topical steroid required for some people.

Allergy to the steroid itself or to an additive in the base of the preparation can sometimes occur. If the eczema gets worse after using a particular topical steroid, let your doctor or nurse know. Cream preparations contain more additives than ointments, so switching to an ointment preparation might help. Also be aware that topical steroids can suppress the symptoms of skin infection, so always check with your healthcare professional if you suspect you have a skin infection.

Fear of side effects can make people under-treat their eczema by stopping a treatment too soon or not using enough of it. This can be detrimental to the overall management of the condition and may mean that a stronger topical steroid has to be used to bring the eczema under control again.

In the UK, topical steroid preparations are divided into four categories according to how strong or potent they are. These categories are ‘mild’, ‘moderate’, ‘potent’ and ‘very potent’. The potency of topical steroids is determined by the amount of vasoconstriction (narrowing of the blood vessels) they produce. It also relates to the degree to which the topical steroid inhibits inflammation, and its potential for causing side effects.

It can be difficult for the person with eczema or the parent of a child with eczema to find out the potency of a product, since potency is not usually stated on the tube or packaging, and the labelled percentage of steroid is different from the potency. The potency of the topical steroid may be stated in the patient information leaflet inside the packaging.

One way of understanding the strength of different steroid preparations is to note that ‘moderate’ is twice as potent as hydrocortisone 1%; ‘potent’ is 10 times more potent; and ‘very potent’ at least 50 times more potent. If you are not sure of the potency of a steroid preparation, ask your pharmacist. A list is provided in the factsheet at the bottom of this page, but new preparations may not be included.

The potency of the steroid you are given will be based on several factors:

• Age: Babies and children with mild to moderate eczema are usually prescribed mild topical steroids. Sometimes, when eczema is more severe or there is no response to a mild steroid, moderate to potent topical steroids may be prescribed for short periods under medical supervision.

• Severity of the eczema: A mild or moderate steroid may be replaced by one of a higher potency if symptoms become more severe, and mild or moderate steroids are not able to bring a flare-up under control.

• Area of the body affected: Areas of thick skin, such as the soles, palms and scalp can be treated with potent preparations. For thinner skin, such as the face and genital areas, mild and moderate preparations are commonly prescribed. A potent steroid will only be used for severe, unresponsive eczema in these areas for a limited period. If a steroid is applied to body folds (for example, the armpits or the skin between the buttocks), the occlusive effect increases its potency, so milder preparations should be used.

• Size of the affected area: A weaker steroid might be prescribed when a large area of skin requires treatment.

• Other treatments: If bandaging forms part of the treatment, a weaker steroid may be chosen because bandaging will increase the amount of steroid getting into the skin.

You may be given more than one topical steroid to treat eczema in different areas of the body. Make sure you understand which preparation should be used where. If in doubt, talk to your pharmacist or contact your doctor or nurse.